Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study,Alzheimer's & Dementia

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Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-08-28 , DOI: 10.1002/alz.14098
Rebecca G Smith ₁ , Ehsan Pishva _{1,

2} , Morteza Kouhsar ₁ , Jennifer Imm ₁ , Valerija Dobricic ₃ , Peter Johannsen ₄ , Michael Wittig ₅ , Andre Franke ₅ , Rik Vandenberghe ₆ , Jolien Schaeverbeke ₆ , Yvonne Freund-Levi _{7,

8,

9} , Lutz Frölich ₁₀ , Philip Scheltens ₁₁ , Charlotte E Teunissen ₁₂ , Giovanni Frisoni ₁₃ , Olivier Blin ₁₄ , Jill C Richardson ₁₅ , Régis Bordet ₁₆ , Sebastiaan Engelborghs _{17,

18} , Ellen de Roeck ₁₇ , Pablo Martinez-Lage ₁₉ , Miren Altuna ₁₉ , Mikel Tainta ₁₉ , Alberto Lleó ₂₀ , Isabel Sala ₂₀ , Julius Popp ₂₁ , Gwendoline Peyratout ₂₂ , Laura Winchester ₂₃ , Alejo Nevado-Holgado ₂₃ , Frans Verhey ₂ , Magda Tsolaki ₂₄ , Ulf Andreasson ₂₅ , Kaj Blennow _{25,

26,

27} , Henrik Zetterberg _{25,

28,

29,

30,

31} , Johannes Streffer ₃₂ , Stephanie J B Vos ₂ , Simon Lovestone _{22,

33} , Pieter Jelle Visser _{2,

11} , Lars Bertram ₃ , Katie Lunnon ₁

Affiliation

Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK.
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands.
Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany.
Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Laboratory for Cognitive Neurology, KU Leuven, Leuven Brain Institute, Leuven, Belgium.
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
School of Medical Sciences, Örebro University, Örebro, Sweden.
Department of Geriatrics, Södertälje Hospital, Södertälje, Sweden.
Department of Geriatric Psychiatry, Central Institut of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Memory center, Geneva University and University Hospitals; on behalf of the AMYPAD consortium, Geneva, Switzerland.
Aix-Marseille University-CNRS, Marseille, France.
Neuroscience Therapeutic Area, GlaxoSmithKline R&D, Stevenage, Hertfordshire, UK.
Université de Lille, Lille, Cedex, France.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Jette, Brussels, Belgium.
Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain.
Servicio de Neurología, Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Hospital Sant Pau, Barcelona, Spain.
University Hospital of Psychiatry Zürich, University of Zürich, Zürich, Switzerland.
Department of Psychiatry, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Department of Psychiatry, University of Oxford, Oxford, UK.
1st Department of Neurology, School of Medicine, Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, and Alzheimer Hellas, Thessaloniki, Greece.
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, PR China.
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, N.T., Shatin, Hong Kong, China.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Translational Medicine Neuroscience, UCB Biopharma SRL, Brussels, Belgium.
Currently at: Johnson & Johnson Innovative Medicines, Beerse, Belgium.

We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration.

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