No value of non-selective beta-blockers after TIPS-insertion,Alimentary Pharmacology & Therapeutics

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No value of non-selective beta-blockers after TIPS-insertion
Alimentary Pharmacology & Therapeutics ( IF 6.6 ) Pub Date : 2024-08-27 , DOI: 10.1111/apt.18204
Anja Tiede _{1,

2} , Lena Stockhoff ₁ , Hannah Rieland ₁ , Zhaoli Liu _{3,

4} , Jim B Mauz ₁ , Tammo L Tergast ₁ , Martin A Kabelitz ₁ , Sarah S Schütte ₁ , Alena F Ehrenbauer ₁ , Bernhard C Meyer ₅ , Heiner Wedemeyer _{1,

2} , Jan B Hinrichs _{5,

6} , Markus Cornberg _{1,

2,

3} , Christine S Falk ₇ , Cheng-Jian Xu _{3,

4} , Benjamin Maasoumy _{1,

2}

Affiliation

Non-selective beta-blockers (NSBB) are a well-established treatment in patients with clinically significant portal hypertension. However, their potential role after insertion of a transjugular intrahepatic portosystemic shunt (TIPS) still needs to be determined. Of note, recent studies suggested that favourable anti-inflammatory effects of NSBB might be independent from pressure reduction. This study aimed to evaluate whether NSBB-treatment is associated with amelioration of systemic inflammation (SI), hepatic decompensation and survival after TIPS-insertion.

中文翻译：

TIPS 插入后非选择性 β 受体阻滞剂没有价值

非选择性β受体阻滞剂（NSBB）是治疗有临床意义的门脉高压患者的一种行之有效的治疗方法。然而，它们在插入经颈静脉肝内门体分流术（TIPS）后的潜在作用仍需确定。值得注意的是，最近的研究表明 NSBB 的良好抗炎作用可能与压力降低无关。本研究旨在评估 NSBB 治疗是否与 TIPS 插入后全身炎症 (SI) 的改善、肝脏代偿失调和生存相关。

更新日期：2024-08-27

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