Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats,Molecular Nutrition & Food Research

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Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-08-28 , DOI: 10.1002/mnfr.202400399
Lisard Iglesias-Carres ₁ , Anna Mas-Capdevila ₁ , Francisca I Bravo _{1,

2,

3} , Manuel Suárez _{1,

2,

3} , Anna Arola-Arnal _{1,

2,

3} , Begoña Muguerza _{1,

2,

3}

Affiliation

The absorption, disposition, metabolism, and excretion (ADME) of phenolic compounds are key factors in determining their bioactivity. The group demonstrates that the ADME of a Grape Seed Proanthocyanidin Extract (GSPE) depends on sex in adult rats and specifically, methylated metabolites are only quantified in brain male adult rats. The aim of this study is to determine whether these differences exist before puberty.

中文翻译：

青春期前大鼠葡萄籽原花青素吸收、处置、代谢和排泄的性别差异

酚类化合物的吸收、处置、代谢和排泄（ADME）是决定其生物活性的关键因素。研究小组证明，葡萄籽原花青素提取物 (GSPE) 的 ADME 取决于成年大鼠的性别，具体而言，甲基化代谢物仅在雄性成年大鼠的大脑中进行定量。本研究的目的是确定这些差异在青春期之前是否存在。

更新日期：2024-08-28

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