Mechanochemistry is an environmentally friendly synthetic approach that enables the sustainable production of a wide range of chemicals while reducing or eliminating the need for solvents. Reactive extrusion aims to move mechanochemistry from its conventional gram-scale batch reactions, typically performed in laboratory ball mills, to a continuous, large-scale process. Meeting this challenge requires in situ monitoring techniques to gain insights into reactive extrusion and its underlying processes. While the effectiveness of in situ Raman spectroscopy in providing molecular-level information has been demonstrated, our study uses energy-dispersive X-ray diffraction to monitor reactive extrusion in real time at the crystalline level. Our results provide previously unavailable control over the reactive extrusion process, promoting its perception as an industrially feasible green alternative to traditional solvent-based syntheses.

中文翻译：

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点亮工业机械化学：使用能量色散 X 射线衍射对反应挤出进行实时原位监测


机械化学是一种环保的合成方法，能够可持续地生产各种化学品，同时减少或消除对溶剂的需求。反应挤出旨在将机械化学从通常在实验室球磨机中进行的传统克级间歇反应转变为连续的大规模工艺。应对这一挑战需要原位监测技术，以深入了解反应挤出及其基本过程。虽然原位拉曼光谱在提供分子水平信息方面的有效性已经得到证明，但我们的研究使用能量色散 X 射线衍射在晶体水平上实时监测反应性挤出。我们的结果提供了以前无法对反应性挤出工艺的控制，促进了其作为传统溶剂型合成的工业上可行的绿色替代品的认知。