Biosensors for Parkinson’s Disease: Where Are We Now, and Where Do We Need to Go?,ACS Sensors

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Biosensors for Parkinson’s Disease: Where Are We Now, and Where Do We Need to Go?
ACS Sensors ( IF 8.2 ) Pub Date : 2024-08-27 , DOI: 10.1021/acssensors.4c00790
Grace M Maddocks ₁ , M Eisenstein _{1,

2} , H Tom Soh _{1,

2}

Affiliation

Parkinson’s Disease is the second most common neurological disease in the United States, yet there is no cure, no pinpointed cause, and no definitive diagnostic procedure. Parkinson’s is typically diagnosed when patients present with motor symptoms such as slowness of movement and tremors. However, none of these are specific to Parkinson’s, and a confident diagnosis of Parkinson’s is typically only achieved when 60–80% of dopaminergic neurons are no longer functioning, at which point much of the damage to the brain is irreversible. This Perspective details ongoing efforts and accomplishments in biosensor research with the goal of overcoming these issues for Parkinson’s diagnosis and care, with a focus on the potential impact of early diagnosis and associated opportunities to pinpoint a cause and a cure. We critically analyze the strengths and shortcomings of current technologies and discuss the ideal characteristics of a diagnostic technology toolbox to guide future research decisions in this space. Finally, we assess what role biosensors can play in facilitating precision medicine for Parkinson’s patients.

中文翻译：

帕金森病生物传感器：我们现在在哪里，我们需要去哪里？

帕金森病是美国第二大常见的神经系统疾病，但尚无治愈方法、没有明确的病因，也没有明确的诊断程序。帕金森氏症通常在患者出现运动缓慢和颤抖等运动症状时被诊断出来。然而，这些都不是帕金森氏症特有的，并且通常只有当 60-80% 的多巴胺能神经元不再发挥作用时，才能对帕金森氏症做出可靠的诊断，此时大脑的大部分损伤是不可逆转的。本视角详细介绍了生物传感器研究中正在进行的努力和成就，其目标是克服帕金森氏症诊断和护理的这些问题，重点关注早期诊断的潜在影响以及查明病因和治疗的相关机会。我们批判性地分析当前技术的优点和缺点，并讨论诊断技术工具箱的理想特征，以指导该领域未来的研究决策。最后，我们评估生物传感器在促进帕金森病患者的精准医疗方面可以发挥什么作用。

更新日期：2024-08-27

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