Association of ventricular–arterial coupling with biomarkers involved in heart failure pathophysiology – the STANISLAS cohort,European Journal of Heart Failure

当前位置： X-MOL 学术 › Eur. J. Heart Fail. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Association of ventricular–arterial coupling with biomarkers involved in heart failure pathophysiology – the STANISLAS cohort
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-08-27 , DOI: 10.1002/ejhf.3411
Hannes Holm _{1,

2} , Martin Magnusson _{1,

2,

3,

4} , Amra Jujić _{1,

2} , Jérémy Lagrange ₅ , Erwan Bozec ₅ , Zohra Lamiral ₅ , Emmanuel Bresso ₅ , Olivier Huttin ₅ , Guillaume Baudry ₅ , Luca Monzo ₅ , Patrick Rossignol ₅ , Faiez Zannad ₅ , Nicolas Girerd ₅

Affiliation

AimsImpaired left ventricular–arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population‐based cohort of middle‐aged individuals.Methods and resultsIn the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF‐related proteins with non‐invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (Ea)/ventricular end‐systolic elastance (Ees). Among the 32 tested proteins, fatty acid‐binding protein adipocyte 4, interleukin‐6, growth differentiation factor 15, matrix metalloproteinase (MMP)‐1, and MMP‐9 and adrenomedullin were positively associated with PWV/GLS whereas transforming growth factor beta receptor type 3, MMP‐2 and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) were negatively associated. In multivariable models, only MMP‐2 and NT‐proBNP were significantly and inversely associated with PWV/GLS in the whole population and in the parent generation. Higher levels of NT‐proBNP were also negatively associated with Ea/Ees in the whole cohort but this association did not persist in the parent subgroup.ConclusionElevated MMP‐2 and NT‐proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.

中文翻译：

心室-动脉耦合与心力衰竭病理生理学生物标志物的关联——STANISLAS队列

目的左心室-动脉耦合 (VAC) 受损已被证明与心脏病和心力衰竭 (HF) 的预后较差相关。 VAC 和与 HF 相关的循环生物标志物之间的关系程度几乎没有记录。我们的目的是在一大群中年个体中探索 VAC 与参与心力衰竭病理生理学的蛋白质之间的关联。方法和结果在 STANISLAS 家族队列的第四次访问中，涉及 1309 名参与者（平均年龄 48 ± 14 岁；48来自父母和子女的男性百分比），我们使用脉搏波速度（PWV）/整体纵向应变（GLS）和动脉弹性（Ea）/心室收缩末期分析了 32 种 HF 相关蛋白与无创评估 VAC 的关联弹性（Ees）。在 32 种测试的蛋白质中，脂肪酸结合蛋白脂肪细胞 4、白细胞介素 6、生长分化因子 15、基质金属蛋白酶 (MMP)-1、MMP-9 和肾上腺髓质素与 PWV/GLS 呈正相关，而转化生长因子 β 受体3 型、MMP-2 和 N 端 B 型利钠肽原 (NT-proBNP) 呈负相关。在多变量模型中，在整个人群和父辈中，只有 MMP-2 和 NT-proBNP 与 PWV/GLS 显着呈负相关。在整个队列中，较高水平的 NT-proBNP 也与 Ea/Ees 呈负相关，但这种相关性在父亚组中并不持续存在。结论：升高的 MMP-2 和 NT-proBNP 水平可能与更好的 VAC（较低的 PWV/GLS）相关。表明在心脏重塑和超负荷过程中调节左心室压力的代偿性心血管反应。

更新日期：2024-08-27

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南