Site-selective acylation of remote arene C(sp2)−H bonds is achieved through N-heterocyclic carbene organocatalysis. This catalytic transformation proceeds through a nitrogen radical-mediated pathway and enables the late-stage modification of drugs, amino acids and peptides under mild conditions.

中文翻译：

---

远程芳烃C-H键的有机催化酰化


远程芳烃 C(sp2)−H 键的位点选择性酰化是通过 N-杂环卡宾有机催化实现的。这种催化转化通过氮自由基介导的途径进行，并能够在温和条件下对药物、氨基酸和肽进行后期修饰。