Objectives To describe antibiotic use in patients with inflammatory arthritis (IA) and in the background population (BP) within one year before and after IA diagnosis. Methods Using data from Danish nationwide registries, we identified all adults with a first-time diagnosis of RA, PsA, or AS/spondyloarthritis (AS/SpA) from 2010 through 2018. For each IA patient, we randomly sampled 10 persons from the BP, matched on sex and birthdate. We calculated the prevalence (n [%]) of any antibiotic dispensing and the total antibiotic dispensing in the year before and after diagnosis. Results We identified 28 504 new-onset IA patients (RA, n = 16 130; PsA, n = 5988; AS/SpA, n = 6386) and 285 040 BP individuals. Within one year before diagnosis, the total amount of dispensed antibiotics was higher in both RA, PsA and As/SpA compared with the BP (prevalence rate ratios [PRR], 1.48 [1.46; 1.51]; 1.67 [1.62; 1.72]; 1.52 [1.47; 1.56], respectively). The amount increased with 22% in IA patients three months before diagnosis compared with the preceding three-month period. Although the prevalence of any antibiotic dispensing in IA patients decreased in the year following the diagnosis (IA; 40.6%), the total one-year antibiotic dispensing remained constant in RA (PRR 0.99 [0.97; 1.01]), decreased in PsA (0.91 [0.87; 0.94]) and increased in AS/SpA (1.08 [1.04; 1.12]) patients after diagnosis compared with before. Conclusion Antibiotics are more frequently dispensed to individuals developing IA compared with the BP. Antibiotic utilization patterns change after IA diagnosis with marked differences among IA subgroups.

中文翻译：

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诊断前后 1 年炎症性关节炎和背景人群中的抗生素：一项全国性的药物使用研究


目的 描述炎症性关节炎 （IA） 患者和背景人群 （BP） 在 IA 诊断前后 1 年内的抗生素使用情况。方法使用来自丹麦全国登记处的数据，我们确定了 2010 年至 2018 年首次诊断为 RA、PsA 或 AS/脊柱关节炎 （AS/SpA） 的所有成年人。对于每位 IA 患者，我们从 BP 中随机抽样了 10 人，根据性别和出生日期进行匹配。我们计算了诊断前后一年内任何抗生素配药的患病率 （n [%]） 和抗生素总配药量。结果 我们确定了 28 504 例新发 IA 患者 （RA，n = 16 130;PsA，n = 5988;AS/SpA，n = 6386）和 285 040 BP 个体。在诊断前一年内，RA、PsA 和 As/SpA 配发抗生素的总量高于血压（患病率比 [PRR]，分别为 1.48 [1.46;1.51]、1.67 [1.62;1.72]、1.52 [1.47;1.56]）。与前 3 个月相比，IA 患者在诊断前 3 个月的量增加了 22%。尽管 IA 患者在诊断后一年内任何抗生素配药的流行率 （IA;40.6%），但 RA 患者的一年抗生素总配药量保持不变 （PRR 0.99 [0.97; 1.01]），PsA 降低 （0.91 [0.87;0.94]），诊断后 AS/SpA 患者 （1.08 [1.04; 1.12]） 与诊断前相比增加。结论 与血压相比，发生 IA 的个体更频繁地分配抗生素。IA 诊断后抗生素使用模式发生变化，IA 亚组之间存在显着差异。