Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants,Cell Host & Microbe

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Clinical sequelae of gut microbiome development and disruption in hospitalized preterm infants
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-08-27 , DOI: 10.1016/j.chom.2024.07.027
Robert Thänert ₁ , Drew J Schwartz ₂ , Eric C Keen ₃ , Carla Hall-Moore ₄ , Bin Wang ₁ , Nurmohammad Shaikh ₄ , Jie Ning ₁ , L Colleen Rouggly-Nickless ₄ , Anna Thänert ₁ , Aura Ferreiro ₁ , Skye R S Fishbein ₁ , Janice E Sullivan ₅ , Paula Radmacher ₅ , Marilyn Escobedo ₆ , Barbara B Warner ₄ , Phillip I Tarr ₇ , Gautam Dantas ₈

Affiliation

The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Diseases Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Pediatrics, University of Louisville School of Medicine, Norton Children's Hospital, Louisville, KY 40202, USA.
Department of Pediatrics, University of Oklahoma, Oklahoma City, OK 73104, USA.
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

Aberrant preterm infant gut microbiota assembly predisposes to early-life disorders and persistent health problems. Here, we characterize gut microbiome dynamics over the first 3 months of life in 236 preterm infants hospitalized in three neonatal intensive care units using shotgun metagenomics of 2,512 stools and metatranscriptomics of 1,381 stools. Strain tracking, taxonomic and functional profiling, and comprehensive clinical metadata identify Enterobacteriaceae, enterococci, and staphylococci as primarily exploiting available niches to populate the gut microbiome. Clostridioides difficile lineages persist between individuals in single centers, and Staphylococcus epidermidis lineages persist within and, unexpectedly, between centers. Collectively, antibiotic and non-antibiotic medications influence gut microbiome composition to greater extents than maternal or baseline variables. Finally, we identify a persistent low-diversity gut microbiome in neonates who develop necrotizing enterocolitis after day of life 40. Overall, we comprehensively describe gut microbiome dynamics in response to medical interventions in preterm, hospitalized neonates.

中文翻译：

住院早产儿肠道菌群发育和破坏的临床后遗症

异常的早产儿肠道微生物群组装容易导致早期生活障碍和持续的健康问题。在这里，我们使用 2,512 例粪便的鸟枪法宏基因组学和 1,381 例粪便的元转录组学表征了在三个新生儿重症监护病房住院的 236 名早产儿出生后前 3 个月的肠道微生物组动力学。菌株跟踪、分类学和功能分析以及全面的临床元数据确定肠杆菌科、肠球菌和葡萄球菌主要利用可用的生态位来填充肠道微生物组。艰难梭菌谱系在单个中心的个体之间持续存在，而表皮葡萄球菌谱系在中心内和中心之间持续存在，出乎意料地在中心之间。总的来说，抗生素和非抗生素药物对肠道微生物组组成的影响程度大于母体或基线变量。最后，我们在出生后一天发生坏死性小肠结肠炎的新生儿中确定了持续的低多样性肠道微生物组 40。总体而言，我们全面描述了肠道微生物组动态对早产、住院新生儿的医疗干预。

更新日期：2024-08-27

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