Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery,Journal of Medicinal Chemistry

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Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2024-08-26 , DOI: 10.1021/acs.jmedchem.4c01550
Anshu Sharma ₁ , Yea Rock Park ₁ , Aman Garg _{2,

3} , Bong-Seop Lee ₁

Affiliation

Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug’s shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector.

中文翻译：

低共熔溶剂增强药物溶解度及其输送

低共熔溶剂 (DES) 是环境友好型溶剂，具有溶解生物活性化合物而不影响其特性的潜力。 DES 具有特殊的品质，可以根据各种治疗需求进行定制，以满足生物分子/活性药物成分 (API) 的独特特性，通过解决溶解度问题，为创建尖端药物配方提供可靠的方法药剂学问题。这项研究概述了新开发的方法来解决由于溶解度差而导致 API 提取效率低下的问题。这些新兴策略还能够改变 API 的化学和物理稳定性，从而延长药物的保质期及其可能的健康益处。预计将开发重点方法和工艺，以利用 DES 的潜力来提高制药领域的药物溶解度和输送。

更新日期：2024-08-26

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