Comparative Efficacy of Biologics and Small Molecule in Ulcerative Colitis: A Systematic Review and Network Meta-analysis,Clinical Gastroenterology and Hepatology

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Comparative Efficacy of Biologics and Small Molecule in Ulcerative Colitis: A Systematic Review and Network Meta-analysis
Clinical Gastroenterology and Hepatology ( IF 11.6 ) Pub Date : 2024-09-05 , DOI: 10.1016/j.cgh.2024.07.033
Mohammad Shehab ₁ , Fatema Alrashed ₂ , Abdulwahab Alsayegh ₃ , Usama Aldallal ₃ , Christopher Ma ₄ , Neeraj Narula ₅ , Vipul Jairath ₆ , Siddharth Singh ₇ , Talat Bessissow ₈

Affiliation

Division of Gastroenterology, Department of Internal Medicine, Mubarak Alkabeer, University Hospital, Kuwait; Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Jabriya, Kuwait.
Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Jabriya, Kuwait.
Department of medicine, School of Medicine, Royal College of Surgeons in Ireland, Medical University of Bahrain, Kingdom of Bahrain.
Division of Gastroenterology and Hepatology, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Canada.
Department of Medicine (Division of Gastroenterology) and Farncombe Family Digestive Health Research Institute; McMaster University, Hamilton ON, Canada.
Department of Medicine, Division of Gastroenterology, Western University, London, ON, Canada; Department of Epidemiology & Biostatistics, Western University, London, ON, Canada.
Division of Gastroenterology, Department of Medicine, University of California, San Diego , La Jolla, CA, USA.
Division of Gastroenterology and Hepatology, Department of Medicine, McGill University Health Center, Montreal, Canada.

Treatment options for moderate to severe ulcerative colitis (UC) are increasing rapidly, but the lack of comparative efficacy trials makes treatment choices a clinical challenge. This network-meta-analysis aimed to compare the relative efficacy of biologics and small molecules in achieving remission in patients with moderate to severe UC.

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