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Ancestral Diversity in Pharmacogenomics Affects Treatment for Hispanic/Latine Populations With Inflammatory Bowel Disease
Clinical Gastroenterology and Hepatology ( IF 11.6 ) Pub Date : 2024-08-23 , DOI: 10.1016/j.cgh.2024.07.032 Stephanie Ioannou 1 , Ashley Beecham 2 , Lissette Gomez 2 , Ryan Dauer 1 , Nicah Khakoo 1 , Lauren Pascual 1 , Maria Quintero 1 , Joanna Lopez 3 , James S Leavitt 3 , Norma Solis 1 , Mailenys Ortega 1 , Amar R Deshpande 1 , David H Kerman 1 , Siobahn Proksell 1 , Esther A Torres 4 , Talin Haritunians 5 , Dalin Li 5 , Maria T Abreu 1 , Dermott P B McGovern 5 , Jacob L McCauley 2 , Oriana M Damas 1
Clinical Gastroenterology and Hepatology ( IF 11.6 ) Pub Date : 2024-08-23 , DOI: 10.1016/j.cgh.2024.07.032 Stephanie Ioannou 1 , Ashley Beecham 2 , Lissette Gomez 2 , Ryan Dauer 1 , Nicah Khakoo 1 , Lauren Pascual 1 , Maria Quintero 1 , Joanna Lopez 3 , James S Leavitt 3 , Norma Solis 1 , Mailenys Ortega 1 , Amar R Deshpande 1 , David H Kerman 1 , Siobahn Proksell 1 , Esther A Torres 4 , Talin Haritunians 5 , Dalin Li 5 , Maria T Abreu 1 , Dermott P B McGovern 5 , Jacob L McCauley 2 , Oriana M Damas 1
Affiliation
The prevalence of inflammatory bowel disease among Hispanic/Latine communities is increasing. Pharmacogenomic studies reveal genetic markers that influence treatment decisions. The aim of our study was to examine the frequency and impact of genetic polymorphisms on thiopurine-associated leukopenia (NUDT15 , TPMT ) and anti-tumor necrosis factor (TNF) immunogenicity (HLA-DQA1∗05 ) in a cohort of Hispanic patients of diverse ancestral backgrounds.
中文翻译：
药物基因组学的祖先多样性影响西班牙裔/拉丁裔炎症性肠病患者的治疗
西班牙裔/拉丁裔社区中炎症性肠病的患病率正在增加。药物基因组学研究揭示了影响治疗决策的遗传标记。我们研究的目的是在一组不同种族的西班牙裔患者中检查遗传多态性对硫嘌呤相关白细胞减少症（NUDT15、TPMT）和抗肿瘤坏死因子（TNF）免疫原性（HLA-DQA1*05）的频率和影响。祖传背景。
更新日期：2024-08-23
中文翻译：
药物基因组学的祖先多样性影响西班牙裔/拉丁裔炎症性肠病患者的治疗
西班牙裔/拉丁裔社区中炎症性肠病的患病率正在增加。药物基因组学研究揭示了影响治疗决策的遗传标记。我们研究的目的是在一组不同种族的西班牙裔患者中检查遗传多态性对硫嘌呤相关白细胞减少症（NUDT15、TPMT）和抗肿瘤坏死因子（TNF）免疫原性（HLA-DQA1*05）的频率和影响。祖传背景。
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