Predictive pharmacodynamic performance of the Eleveld pharmacokinetic–pharmacodynamic model for propofol: comparison of predicted and measured bispectral index,British Journal of Anaesthesia

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Predictive pharmacodynamic performance of the Eleveld pharmacokinetic–pharmacodynamic model for propofol: comparison of predicted and measured bispectral index
British Journal of Anaesthesia ( IF 9.1 ) Pub Date : 2024-08-23 , DOI: 10.1016/j.bja.2024.06.041
Ettienne Coetzee ₁ , Johan F Coetzee ₂ , Marlis Haasbroek ₁

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The Eleveld pharmacokinetic–pharmacodynamic model for propofol predicts bispectral index (BIS) processed electroencephalogram values from estimated effect-site concentrations. We investigated agreement between measured and predicted BIS values during total intravenous anaesthesia (TIVA).

中文翻译：

异丙酚 Eleveld 药代动力学-药效模型的预测药效性能：预测和测量的脑电双频指数的比较

异丙酚的 Eleveld 药代动力学-药效学模型根据估计的效应位点浓度预测脑电双频指数 (BIS) 处理后的脑电图值。我们研究了全静脉麻醉 (TIVA) 期间测量的 BIS 值与预测的 BIS 值之间的一致性。

更新日期：2024-08-23

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