Jiang et al. show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization of activated endothelial nitric oxide synthase on subcellular vesicles. The study demonstrates that zinc finger FYVE-type containing 21 could modulate the levels of caveolin-1 in glomerular endothelial cells using vesicle-based trafficking, thereby supporting endothelial nitric oxide synthase activity. The authors provide evidence that decreased zinc finger FYVE-type containing 21 expression in glomerular endothelial cells could play a role in aging-related glomerular filtration barrier dysfunction.

中文翻译：

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肾脏老化揭示了内皮功能障碍的潜在机制。


江 等人表明，含有 21 的锌指 FYVE 型，肾小球内皮细胞中的 Rab5 效应器通过稳定亚细胞囊泡上活化的内皮一氧化氮合酶参与维持肾小球滤过屏障稳态。研究表明，含有 21 的锌指 FYVE 型可以使用基于囊泡的运输来调节肾小球内皮细胞中 caveolin-1 的水平，从而支持内皮一氧化氮合酶活性。作者提供的证据表明，肾小球内皮细胞中含有 21 的锌指 FYVE 型表达降低可能在衰老相关的肾小球滤过屏障功能障碍中发挥作用。