Previous studies of the immune control of cytomegalovirus infection have primarily focused on analysis of the traditional adaptive T-cell response. Donadeu et al. bring a new perspective through evaluation of multiple adaptive and innate immune subtypes in parallel with cytomegalovirus-specific cell-mediated immunity in a prospective cohort of kidney transplant recipients with findings validated in 2 independent studies. Identification of a natural killer T-cell subtype associated with cell-mediated immunity and freedom from cytomegalovirus infection demonstrates the importance of the coordinated innate and adaptive immune response for effective viral control.

中文翻译：

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适应性免疫系统和先天免疫系统相互协调，成功控制 CMV 感染。


先前对巨细胞病毒感染的免疫控制的研究主要集中于对传统适应性T细胞反应的分析。多纳杜等人。通过在肾移植受者的前瞻性队列中评估多种适应性和先天免疫亚型以及巨细胞病毒特异性细胞介导的免疫，带来了新的视角，并在两项独立研究中验证了结果。与细胞介导的免疫和免受巨细胞病毒感染相关的自然杀伤 T 细胞亚型的鉴定证明了协调的先天性和适应性免疫反应对于有效控制病毒的重要性。