Yamamoto et al. developed an exciting technical advance to examine intracellular adenosine triphosphate levels with single-cell resolution in intact living kidney tissue, including in tubular and vascular segments that lie deep under the kidney surface. The work is a significant advance on prior in vivo biosensor studies, and it allows for mechanistic investigation of alterations in cell metabolism, kidney disease pathobiology, and the effects of drug treatments on energy sources in different kidney cell types.

中文翻译：

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使用 ATP 生物传感器了解肾细胞的力量。


Yamamoto 等人开发了一项令人兴奋的技术进步，以单细胞分辨率检查完整活体肾组织中的细胞内三磷酸腺苷水平，包括位于肾表面深处的肾小管和血管段。这项工作是先前体内生物传感器研究的重大进步，它允许对细胞代谢的改变、肾脏疾病病理生物学以及药物治疗对不同肾细胞类型中能量来源的影响进行机制研究。