Alzheimer's disease (AD) is the leading cause of dementia worldwide. Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal fluid testing), but these are limited by their high cost, invasiveness, and lack of expertise. Retinal imaging exhibits potential in AD screening and risk stratification, as the retina provides a platform for the optical visualization of the central nervous system in vivo, with vascular and neuronal changes that mirror brain pathology.

中文翻译：

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视网膜成像在阿尔茨海默病筛查中的价值主张：八大不断发展趋势的综述


阿尔茨海默病 （AD） 是全球痴呆的主要原因。目前 AD 的诊断方式通常侧重于检测大脑中淀粉样蛋白 β 和 tau 蛋白的存在（例如，正电子发射断层扫描 [PET] 和脑脊液检测），但这些方法受到其高成本、侵入性和缺乏专业知识的限制。视网膜成像在 AD 筛查和风险分层方面表现出潜力，因为视网膜为体内中枢神经系统的光学可视化提供了一个平台，其血管和神经元变化反映了脑病理学。