The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study.,The American Journal of Gastroenterology

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The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study.
The American Journal of Gastroenterology ( IF 8.0 ) Pub Date : 2024-08-20 , DOI: 10.14309/ajg.0000000000003048
Hajime Yamazaki _{1,

2} , Martin Heni _{3,

4} , Róbert Wagner _{5,

6,

7} , Shunichi Fukuhara _{1,

2,

8} , Steven R Grossman _{9,

10} , Sihao Han ₁₁ , Lang Wu ₁₂ , Samantha A Streicher ₁₂ , Brian Z Huang _{9,

13}

Affiliation

Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University, Fukushima, Japan.
Division of Endocrinology and Diabetology, Department of Internal Medicine I, Ulm University, Ulm, Germany.
Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany.
Department of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich-Heine University, Düsseldorf, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

INTRODUCTION Recent associative studies have linked intrapancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear. METHODS Using Mendelian randomization, we evaluated the causal association between genetically predicted IPFD and pancreatitis. This approach used genetic variants from genomewide association studies of IPFD (n = 25,617), acute pancreatitis (n = 6,787 cases/361,641 controls), and chronic pancreatitis (n = 3,875 cases/361,641 controls). RESULTS Genetically predicted IPFD was significantly associated with acute pancreatitis (odds ratio per 1-SD increase: 1.40 [95% CI: 1.12-1.76], P = 0.0032) and chronic pancreatitis (odds ratio: 1.64 [95% CI: 1.13-2.39], P = 0.0097). DISCUSSION Our findings support a causal role of IPFD in pancreatitis, suggesting that reducing IPFD could lower the risk of pancreatitis.

中文翻译：

胰内脂肪沉积对急性和慢性胰腺炎的因果影响：一项孟德尔随机化研究。

引言最近的关联研究将胰腺内脂肪沉积（IPFD）与胰腺炎风险联系起来，但因果关系仍不清楚。方法使用孟德尔随机化，我们评估了遗传预测的 IPFD 与胰腺炎之间的因果关系。这种方法使用了来自 IPFD （n = 25,617）、急性胰腺炎（n = 6,787 例/361,641 例对照）和慢性胰腺炎（n = 3,875 例/361,641 例对照）的全基因组关联研究的遗传变异。结果遗传预测 IPFD 与急性胰腺炎（每 1-SD 增加比值比： 1.40 [95% CI： 1.12-1.76]，P = 0.0032）和慢性胰腺炎（比值比： 1.64 [95% CI： 1.13-2.39]，P = 0.0097）显著相关。讨论我们的研究结果支持 IPFD 在胰腺炎中的因果作用，表明减少 IPFD 可以降低患胰腺炎的风险。

更新日期：2024-08-20

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