OBJECTIVE This study aims to investigate the association between systemic inflammation, measured by the systemic immune-inflammatory index (SII), and menopausal symptoms in postmenopausal women. METHODS A cross-sectional study was conducted with 702 postmenopausal women recruited from a tertiary hospital. Participants completed the Menopause Rating Scale (MRS) to assess somatic, psychological, and urogenital symptoms. Blood samples were collected to calculate SII. Statistical analyses included correlation, univariate regression, and multivariate regression to determine the association between SII and menopausal symptoms. RESULTS The most commonly reported symptoms were muscle and joint problems (75.9%), hot flashes and sweating (72.5%), sleeping problems (71.2%), and depressive mood (69.9%). Women with higher total and somatic subscale scores had significantly elevated SII levels compared with those with lower scores. SII was the most associated variable for high total MRS (odds ratio, 4.77; 95% CI, 3.36-6.78; P < 0.001) and somatic subscale scores (odds ratio, 6.32; 95% CI, 4.45-8.99; P < 0.001). Exercise and gravidity were negatively associated with high total MRS and somatic subscale scores. Conversely, no significant associations were observed between SII and the urogenital or psychological subscale scores. CONCLUSION Elevated SII levels were found associated with higher somatic subscale and total MRS scores, suggesting that inflammation may contribute to worsened somatic menopausal symptoms in this group. These findings suggest that exploring inflammatory pathways could be beneficial in managing menopausal symptoms and enhancing quality of life for postmenopausal women.

中文翻译：

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全身炎症和更年期症状：来自绝经后妇女的见解。


目的 本研究旨在探讨通过全身免疫炎症指数 （SII） 测量的全身炎症与绝经后妇女更年期症状之间的关联。方法 对从三级医院招募的 702 名绝经后妇女进行横断面研究。参与者完成了更年期评定量表 （MRS） 以评估躯体、心理和泌尿生殖系统症状。采集血样计算 SII。统计分析包括相关性、单变量回归和多变量回归，以确定 SII 与更年期症状之间的关联。结果 最常报告的症状是肌肉和关节问题 （75.9%）、潮热和出汗 （72.5%）、睡眠问题 （71.2%） 和抑郁情绪 （69.9%）。与得分较低的女性相比，总分和体细胞分值较高的女性 SII 水平显著升高。SII 是高总 MRS 最相关的变量 （比值比，4.77;95% CI，3.36-6.78;P < 0.001）和体细胞分量表评分 （比值比，6.32;95% CI，4.45-8.99;P < 0.001）。运动和重力与高总 MRS 和体细胞分量表评分呈负相关。相反，在 SII 与泌尿生殖系统或心理分量表评分之间未观察到显着关联。结论 发现 SII 水平升高与较高的躯体分量表和 MRS 总分相关，表明炎症可能导致该组躯体更年期症状恶化。这些发现表明，探索炎症途径可能有助于控制更年期症状和提高绝经后妇女的生活质量。