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Infantile colic is associated with development of later constipation and atopic disorders.
Allergy ( IF 12.6 ) Pub Date : 2024-08-19 , DOI: 10.1111/all.16274
Jakob Stokholm 1, 2, 3 , Jonathan Thorsen 1 , Ann-Marie Malby Schoos 1, 3 , Morten Arendt Rasmussen 1, 2 , Sarah Brandt 1 , Søren Johannes Sørensen 4 , Nilo Vahman 1 , Bo Chawes 1 , Klaus Bønnelykke 1
Allergy ( IF 12.6 ) Pub Date : 2024-08-19 , DOI: 10.1111/all.16274
Jakob Stokholm 1, 2, 3 , Jonathan Thorsen 1 , Ann-Marie Malby Schoos 1, 3 , Morten Arendt Rasmussen 1, 2 , Sarah Brandt 1 , Søren Johannes Sørensen 4 , Nilo Vahman 1 , Bo Chawes 1 , Klaus Bønnelykke 1
Affiliation
BACKGROUND
Infantile colic is a common condition with limited knowledge about later clinical manifestations. We evaluated the role of the early life gut microbiome in infantile colic and later development of atopic and gastrointestinal disorders.
METHODS
Copenhagen Prospective Studies on Asthma in Childhood2010 cohort was followed with 6 years of extensive clinical phenotyping. The 1-month gut microbiome was analyzed by 16S rRNA sequencing. Infantile colic was evaluated at age 3 months by interviews. Clinical endpoints included constipation to age 3 years and prospectively diagnosed asthma and atopic dermatitis in the first 6 years of life, and allergic sensitization from skin prick tests, specific Immunoglobulin E, and component analyses.
RESULTS
Of 695 children, 55 children (7.9%) had infantile colic. Several factors were associated with colic including race, breastfeeding, and pets. The 1-month gut microbiome composition and taxa abundances were not associated with colic, however a sparse Partial Least Squares model including combined abundances of nine species was moderately predictive of colic: median, cross-validated AUC = 0.627, p = .003. Children with infantile colic had an increased risk of developing constipation (aOR, 2.88 [1.51-5.35], p = .001) later in life, but also asthma (aHR, 1.69 [1.02-2.79], p = .040), atopic dermatitis (aHR, 1.84 [1.20-2.81], p = .005) and had a higher number of positive allergic components (adjusted difference, 116% [14%-280%], p = .012) in the first 6 years. These associations were not mediated by gut microbiome differences.
CONCLUSIONS
We link infantile colic with risk of developing constipation and atopic disorders in the first 6 years of life, which was not mediated through an altered gut microbiome at age 1-month. These results suggest infantile colic to involve gastrointestinal and/or atopic mechanisms.
中文翻译:
婴儿绞痛与晚期便秘和特应性疾病的发展有关。
背景 婴儿绞痛是一种常见病,对以后的临床表现了解有限。我们评估了早期肠道微生物组在婴儿绞痛以及后来特应性和胃肠道疾病发展中的作用。方法 2010 年儿童哮喘队列的哥本哈根前瞻性研究 (Copenhagen Prospective Studies in Childhood in Asthma in Childhood) 进行了 6 年的广泛临床表型分析。通过 16S rRNA 测序分析 1 个月的肠道微生物组。婴儿绞痛在 3 个月大时通过访谈进行评估。临床终点包括 3 岁前便秘和出生后前 6 年前瞻性诊断为哮喘和特应性皮炎,以及皮肤点刺试验、特异性免疫球蛋白 E 和成分分析的过敏致敏。结果 在 695 例儿童中,55 例 (7.9%) 患有婴儿绞痛。几个因素与绞痛有关,包括种族、母乳喂养和宠物。1 个月的肠道微生物组组成和分类群丰度与绞痛无关,但是包括 9 个物种的综合丰度的稀疏偏最小二乘模型对绞痛有中等预测性:中位数,交叉验证的 AUC = 0.627,p = .003。患有婴儿绞痛的儿童在以后的生活中发生便秘的风险增加 (aOR, 2.88 [1.51-5.35],p = .001),但哮喘 (aHR, 1.69 [1.02-2.79],p = .040)、特应性皮炎 (aHR, 1.84 [1.20-2.81],p = .005) 和阳性过敏成分数量增加 (调整后的差异,116% [14%-280%],p = .012) 在前 6 年。这些关联不是由肠道微生物组差异介导的。结论 我们将婴儿绞痛与出生后前 6 年发生便秘和特应性疾病的风险联系起来,这并不是通过 1 个月大时肠道微生物组改变来介导的。 这些结果表明婴儿绞痛涉及胃肠道和/或特应性机制。
更新日期:2024-08-19
中文翻译:
婴儿绞痛与晚期便秘和特应性疾病的发展有关。
背景 婴儿绞痛是一种常见病,对以后的临床表现了解有限。我们评估了早期肠道微生物组在婴儿绞痛以及后来特应性和胃肠道疾病发展中的作用。方法 2010 年儿童哮喘队列的哥本哈根前瞻性研究 (Copenhagen Prospective Studies in Childhood in Asthma in Childhood) 进行了 6 年的广泛临床表型分析。通过 16S rRNA 测序分析 1 个月的肠道微生物组。婴儿绞痛在 3 个月大时通过访谈进行评估。临床终点包括 3 岁前便秘和出生后前 6 年前瞻性诊断为哮喘和特应性皮炎,以及皮肤点刺试验、特异性免疫球蛋白 E 和成分分析的过敏致敏。结果 在 695 例儿童中,55 例 (7.9%) 患有婴儿绞痛。几个因素与绞痛有关,包括种族、母乳喂养和宠物。1 个月的肠道微生物组组成和分类群丰度与绞痛无关,但是包括 9 个物种的综合丰度的稀疏偏最小二乘模型对绞痛有中等预测性:中位数,交叉验证的 AUC = 0.627,p = .003。患有婴儿绞痛的儿童在以后的生活中发生便秘的风险增加 (aOR, 2.88 [1.51-5.35],p = .001),但哮喘 (aHR, 1.69 [1.02-2.79],p = .040)、特应性皮炎 (aHR, 1.84 [1.20-2.81],p = .005) 和阳性过敏成分数量增加 (调整后的差异,116% [14%-280%],p = .012) 在前 6 年。这些关联不是由肠道微生物组差异介导的。结论 我们将婴儿绞痛与出生后前 6 年发生便秘和特应性疾病的风险联系起来,这并不是通过 1 个月大时肠道微生物组改变来介导的。 这些结果表明婴儿绞痛涉及胃肠道和/或特应性机制。