Skeletal muscle fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components and is a hallmark of muscular dystrophies. Fibro-adipogenic progenitors (FAPs) are the main source of ECM, and thus have been strongly implicated in fibrogenesis. In skeletal muscle fibrotic models, including muscular dystrophies, FAPs undergo dysregulations in terms of proliferation, differentiation, and apoptosis, however few studies have explored the impact of FAPs migration.

中文翻译：

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溶血磷脂酸-LPA1-YAP 信号传导参与健康和病理性 FAP 迁移


骨骼肌纤维化被定义为细胞外基质（ECM）成分的过度积累，是肌营养不良症的一个标志。纤维脂肪祖细胞 (FAP) 是 ECM 的主要来源，因此与纤维发生密切相关。在骨骼肌纤维化模型中，包括肌营养不良症，FAP 在增殖、分化和凋亡方面出现失调，但很少有研究探讨 FAP 迁移的影响。