Rapid Uptitration of Guideline-Directed Medical Therapies in Acute Heart Failure With and Without Atrial Fibrillation,JACC: Heart Failure

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Rapid Uptitration of Guideline-Directed Medical Therapies in Acute Heart Failure With and Without Atrial Fibrillation
JACC: Heart Failure ( IF 10.3 ) Pub Date : 2024-08-14 , DOI: 10.1016/j.jchf.2024.06.010
Dimitrios Farmakis ₁ , Beth Davison ₂ , Katerina Fountoulaki ₁ , Sotiria Liori ₁ , Ovidiu Chioncel ₃ , Marco Metra ₄ , Jelena Celutkiene ₅ , Alain Cohen-Solal ₆ , Albertino Damasceno ₇ , Rafael Diaz ₈ , Christopher Edwards ₉ , Etienne Gayat ₁₀ , Maria Novosadova ₉ , Vasiliki Bistola ₁ , Peter S Pang ₁₁ , Piotr Ponikowski ₁₂ , Hadiza Saidu ₁₃ , Karen Sliwa ₁₄ , Koji Takagi ₉ , Adriaan A Voors ₁₅ , Alexandre Mebazaa ₁₆ , Gad Cotter ₂ , Gerasimos Filippatos ₃

Affiliation

Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School, Athens, Greece; Physiology Lab, University of Cyprus Medical School, Nicosia, Cyprus.
Heart Initiative, Durham, North Carolina, USA; Momentum Research Inc, Durham, North Carolina, USA; Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
Emergency Institute for Cardiovascular Diseases "Prof. C.C. Iliescu," University of Medicine "Carol Davila," Bucharest, Romania.
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Paris Cite University, INSERM U946, AP-HP, Lariboisiere Hospital, Paris, France.
Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Estudios Clínicos Latinoamérica, Instituto Cardiovascular de Rosario, Rosario, Argentina.
Momentum Research Inc, Durham, North Carolina, USA.
Université Paris Cité, INSERM UMR-S 942(MASCOT [Cardiovascular MArkers in Stressed COndiTions]), Paris, France.
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
Murtala Muhammed Specialist Hospital, Bayero University Kano, Kano, Nigeria.
Cape Heart Institute, Department of Medicine and Cardiology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Department of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Université Paris Cité, INSERM UMR-S 942(MASCOT), Paris, France; Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis and Lariboisière Hospitals, University Hospital Federation PROMICE (PRecision medicine for cOMprehensIve care of Critically ill patieEnts), Departments Medico-Universitaires Parabol, Assistance Public - Hopitaux de Paris, Paris, France.

Rapid uptitration of guideline-directed medical therapy (GDMT) before and after discharge in hospitalized heart failure (HF) patients is feasible, is safe, and improves outcomes; whether this is also true in patients with coexistent atrial fibrillation/flutter (AF/AFL) is not known.

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