Archaea constitute one of the main 3 domains of the tree of life, distinct from eukaryotes and bacteria. Excessive luminal loads of methanogenic archaea (intestinal methanogen overgrowth [IMO]) have been implicated in the pathophysiology of various diseases, including constipation. To elucidate the phenotypical presentation of IMO, we performed a systematic review and meta-analysis of the prevalence and severity of gastrointestinal symptoms in subjects with IMO as compared with subjects without IMO.

中文翻译：

---

肠道产甲烷菌过度生长患者的症状概况：系统评价和荟萃分析


古细菌构成了生命之树的 3 个主要结构域之一，与真核生物和细菌不同。产甲烷古细菌的过量管腔负荷（肠道产甲烷菌过度生长 [IMO]）与各种疾病的病理生理学有关，包括便秘。为了阐明 IMO 的表型表现，我们对 IMO 受试者与无 IMO 受试者相比胃肠道症状的患病率和严重程度进行了系统评价和荟萃分析。