Sepsis is a major contributor to poor child health outcomes around the world. The high morbidity, mortality, and societal cost associated with paediatric sepsis render it a global health priority, as summarised in Paper 1 of this Series. Sepsis is characterised by a dysregulated host response to infection that manifests as organ failure, and children are uniquely susceptible to sepsis, as discussed in Paper 2. The focus of this third Series paper is quality improvement in paediatric sepsis. The 2017 WHO resolution on sepsis outlined key aims to reduce the burden of sepsis. As of 2024, only a small number of countries have implemented systematic, paediatric-focused quality improvement programmes to raise sepsis awareness, enhance recognition of sepsis, promote timely treatment, and provide long-term support for paediatric sepsis survivors. We examine programme successes and systematic barriers to quality improvement targeting paediatric sepsis. We highlight the need for programme design to consider the entire patient journey, starting with prevention, caregiver awareness, recognition at home, education of the health-care workforce, development of health-care systems, and establishment of long-term family and survivor support extending beyond the intensive care unit. Building on lessons learnt from existing quality improvement programmes, we outline implementation strategies and measures to enable benchmarking. Ultimately, quality improvement on a global scale can only be accelerated through a global learning platform focusing on paediatric sepsis.

中文翻译：

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从全球角度来看儿科败血症的质量改进计划。


脓毒症是导致世界各地儿童健康状况不佳的一个主要原因。正如本系列论文 1 中所总结的，与儿科脓毒症相关的高发病率、死亡率和社会成本使其成为全球卫生优先事项。脓毒症的特点是宿主对感染的反应失调，表现为器官衰竭，而儿童特别容易患脓毒症，如论文 2 中所讨论的。第三个系列论文的重点是儿科脓毒症的质量改进。 2017 年世界卫生组织关于败血症的决议概述了减轻败血症负担的主要目标。截至2024年，只有少数国家实施了系统的、以儿科为重点的质量改进计划，以提高对脓毒症的认识，增强对脓毒症的认识，促进及时治疗，并为儿科脓毒症幸存者提供长期支持。我们研究了针对儿科败血症的项目的成功和质量改进的系统性障碍。我们强调方案设计需要考虑整个患者旅程，从预防、护理人员意识、家庭认可、医疗保健人员教育、医疗保健系统发展以及建立长期家庭和幸存者支持开始范围超出了重症监护室。根据从现有质量改进计划中汲取的经验教训，我们概述了实现基准测试的实施战略和措施。最终，只有通过专注于儿科败血症的全球学习平台才能加速全球范围内的质量改进。