The microbiota, comprising bacteria, fungi, and viruses residing within our bodies, functions as a key modulator in host health and states, including immune responses. Studies have linked microbiota and microbiota-derived metabolites to immune cell functions. In this review, we probe the complex relationship between the human microbiota and clinical outcomes of cellular therapies that leverage immune cells to fight various cancers. With a particular emphasis on hematopoietic cell transplantation and chimeric antigen receptor T-cell therapy, we explore the potential mechanisms underpinning this interaction. We also highlight the interventional applications of the microbiota in cellular therapy while outlining future research directions in the field.

中文翻译：

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肠道菌群和细胞疗法：对影响和机制的影响


微生物群由我们体内的细菌、真菌和病毒组成，是宿主健康和状态（包括免疫反应）的关键调节剂。研究已将微生物群和微生物群衍生的代谢物与免疫细胞功能联系起来。在这篇综述中，我们探讨了人类微生物群与利用免疫细胞对抗各种癌症的细胞疗法的临床结果之间的复杂关系。特别强调造血细胞移植和嵌合抗原受体 T 细胞疗法，我们探索了支持这种相互作用的潜在机制。我们还强调了微生物群在细胞治疗中的介入应用，同时概述了该领域未来的研究方向。