Lyme disease is a zoonotic infection due to Ixodes tick–transmitted Borrelia burgdorferi sensu lato spirochetes and the most common vector-borne disease in the Northern Hemisphere. Despite nearly 50 years of investigation, the pathogenesis of this infection and its 2 main adverse outcomes—postinfectious Lyme arthritis and posttreatment Lyme disease syndrome—are incompletely understood. Advancement in sequencing and mass spectrometry have led to the rapid expansion of high-throughput omics technologies, including transcriptomics, metabolomics, and proteomics, which are now being applied to human diseases. This review summarizes findings of omics studies conducted on blood and tissue samples of people with acute Lyme disease and its postinfectious outcomes.

中文翻译：

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莱姆病组学的见解


莱姆病是一种由硬蜱传播的伯氏疏螺旋体引起的人畜共患感染，是北半球最常见的媒介传播疾病。尽管进行了近 50 年的调查，但这种感染的发病机制及其 2 种主要不良结局（感染后莱姆关节炎和治疗后莱姆病综合征）尚不完全清楚。测序和质谱技术的进步导致了高通量组学技术的快速扩展，包括转录组学、代谢组学和蛋白质组学，这些技术现在正应用于人类疾病。本综述总结了对急性莱姆病患者的血液和组织样本及其感染后结局进行的组学研究结果。