The healing process at a wound is made up of many types of cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex and changing ways. Microbial colonization and proliferation are possible at the place of injury, which makes infection more likely. Because of this, any cut has a chance of getting an infection. Researchers have found that wound infections make patients more upset and cost the healthcare system a lot of money. Surgical site infections happen a lot to people who have recently had surgery. This study shows that such surgical infection is linked to a high rate of illness and death. This is shown by the fact that 25% of patients get serious sepsis and need to be transferred to an intensive care unit. In both animal models and people, mesenchymal stem cells (MSCs) play an active role in all stages of wound healing and have positive effects. Exosomes are one of the main things MSCs release. They have effects that are similar to those of the parent MSCs. Various effector proteins, messenger RNA and microRNAs can be transported by extracellular vesicles to control the activity of target cells. This has a big impact on the healing process. These results suggest that using MSC-exosomes as a new type of cell-free therapy could be a better and safer option than whole cell therapy. This review is mostly about how to use parts of MSC-exosomes to help wound infections heal.

中文翻译：

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间充质干细胞外泌体成分在伤口感染愈合中的应用：新见解。


伤口的愈合过程由多种类型的细胞、生长因子、细胞外基质、神经和血管组成，它们以复杂且变化的方式相互作用。受伤部位可能有微生物定植和增殖，从而更有可能发生感染。因此，任何伤口都有可能受到感染。研究人员发现，伤口感染会让患者更加不安，并使医疗系统花费大量金钱。手术部位感染经常发生在最近接受过手术的人身上。这项研究表明，这种手术感染与高患病率和死亡率有关。 25% 的患者患有严重败血症并需要转移到重症监护室的事实就证明了这一点。无论是在动物模型还是人体中，间充质干细胞（MSC）在伤口愈合的各个阶段都发挥着积极作用，并具有积极作用。外泌体是 MSC 释放的主要物质之一。它们具有与亲代 MSC 相似的作用。各种效应蛋白、信使RNA和微小RNA可以通过细胞外囊泡运输来控制靶细胞的活性。这对愈合过程有很大影响。这些结果表明，使用 MSC 外泌体作为一种新型无细胞疗法可能是比全细胞疗法更好、更安全的选择。这篇综述主要是关于如何使用部分 MSC 外泌体来帮助伤口感染愈合。