Extracellular vesicles are known for intercellular signaling roles but can also serve to simply dispose of unwanted cargoes. In this issue, Bostelman and Broihier discuss new work from Rodal and colleagues (https://doi.org/10.1083/jcb.202405025) that refutes prior work by showing that extracellular vesicles at Drosophila neuromuscular junctions are not required for signaling and instead likely serve a proteostasis role.

中文翻译：

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电动汽车在突触处移动的是混乱，而不是信息。


细胞外囊泡以细胞间信号传导作用而闻名，但也可以用来简单地处理不需要的货物。在本期中，Bostelman 和 Broihier 讨论了 Rodal 及其同事的新工作 (https://doi.org/10.1083/jcb.202405025)，该工作反驳了之前的工作，表明果蝇神经肌肉接头处的细胞外囊泡不是信号传导所必需的，而是可能发挥蛋白质稳态作用。