Low-renin hypertension is common and affects 1 in 4 people with hypertension. Understanding the different causes and management of low-renin hypertension is becoming increasingly relevant as renin measurements are more widely ordered in clinical practice. Importantly, many people with low-renin hypertension do not fit traditional definitions of known causes, and the approach to management of these people is not unclear. This review provides an overview of our evolving understanding of the causes of low-renin hypertension, the expanding spectrums of pathophysiology, key differentiating characteristics, distinct management strategies, and highlights our knowledge gaps. It is important to distinguish the underlying pathophysiology of an individual with low-renin hypertension to individualize treatment.

中文翻译：

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低肾素高血压的最新进展：当前的理解和未来的方向。


低肾素高血压很常见，四分之一的高血压患者受到影响。随着肾素测量在临床实践中得到更广泛的应用，了解低肾素高血压的不同原因和治疗变得越来越重要。重要的是，许多患有低肾素高血压的人不符合已知病因的传统定义，并且这些人的治疗方法尚不清楚。这篇综述概述了我们对低肾素高血压病因的不断发展的理解、不断扩大的病理生理学范围、关键的区分特征、独特的管理策略，并强调了我们的知识差距。区分低肾素高血压患者的潜在病理生理学对于个体化治疗非常重要。