Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids,Environment International

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Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids
Environment International ( IF 10.3 ) Pub Date : 2024-08-15 , DOI: 10.1016/j.envint.2024.108960
Inge Varik ₁ , Runyu Zou ₂ , Andrea Bellavia ₃ , Kristine Rosenberg ₄ , Ylva Sjunnesson ₅ , Ida Hallberg ₆ , Jan Holte ₇ , Virissa Lenters ₈ , Majorie Van Duursen ₈ , Mikael Pedersen ₉ , Terje Svingen ₉ , Roel Vermeulen ₂ , Andres Salumets ₁₀ , Pauliina Damdimopoulou ₁₁ , Agne Velthut-Meikas ₁

Affiliation

Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia; Nova Vita Clinic, Tallinn, Estonia.
Department of Clinical Sciences, Division of Reproduction, The Center for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Clinical Sciences, Division of Reproduction, The Center for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Animal Biosciences, Division of Reproduction, The Center for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Carl von Linné Clinic, Uppsala, Sweden.
Amsterdam Institute for Life and Environment, Section Environmental Health and Toxicology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Competence Center on Health Technologies, Tartu, Estonia; Department of Gynaecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Sweden; Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Department of Gynaecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Sweden.

The plasticizer di(2-ethylhexyl) phthalate (DEHP) is known to have endocrine-disrupting properties mediated by its many metabolites that form upon exposure in biological systems. In a previous study, we reported an inverse association between DEHP metabolites in the human ovarian follicular fluid (FF) and the responsiveness of the follicles to controlled ovarian stimulation during in vitro fertilization (IVF) treatments. Here, we explored this association further through molecular analysis of the ovarian FF samples.

中文翻译：

卵巢胆固醇和类固醇生物合成减少以及炎症增加与人卵巢卵泡液中 DEHP 代谢物水平较高有关

众所周知，增塑剂邻苯二甲酸二(2-乙基己基)酯 (DEHP) 具有内分泌干扰特性，这是由其在生物系统中暴露后形成的许多代谢物介导的。在之前的一项研究中，我们报道了人卵巢卵泡液 (FF) 中的 DEHP 代谢物与体外受精 (IVF) 治疗期间卵泡对受控卵巢刺激的反应性之间存在负相关。在这里，我们通过对卵巢 FF 样本的分子分析进一步探讨了这种关联。

更新日期：2024-08-15

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