Most secreted proteins are transported through the "conventional" endoplasmic reticulum-Golgi apparatus exocytic route for their delivery to the cell surface and release into the extracellular space. Nonetheless, formative discoveries have underscored the existence of alternative or "unconventional" secretory routes, which play a crucial role in exporting a diverse array of cytosolic proteins outside the cell in response to intrinsic demands, external cues, and environmental changes. In this context, lysosomes emerge as dynamic organelles positioned at the crossroads of multiple intracellular trafficking pathways, endowed with the capacity to fuse with the plasma membrane and recognized for their key role in both conventional and unconventional protein secretion. The recent recognition of lysosomal transport and exocytosis in the unconventional secretion of cargo proteins provides new and promising insights into our understanding of numerous physiological processes.

中文翻译：

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内溶酶体系统进行常规和非常规蛋白质分泌。


大多数分泌蛋白通过“传统”内质网-高尔基体胞吐途径运输至细胞表面并释放到细胞外空间。尽管如此，形成性的发现强调了替代或“非常规”分泌途径的存在，这些途径在响应内在需求、外部线索和环境变化而将多种胞质蛋白输出到细胞外方面发挥着至关重要的作用。在这种情况下，溶酶体作为动态细胞器出现，位于多个细胞内运输途径的十字路口，具有与质膜融合的能力，并因其在常规和非常规蛋白质分泌中的关键作用而被认可。最近对货物蛋白非常规分泌中溶酶体运输和胞吐作用的认识为我们对众多生理过程的理解提供了新的、有前景的见解。