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Fusion event mediated by IS903B between chromosome and plasmid in two MCR-9- and KPC-2-co-producing Klebsiella pneumoniae isolates
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2024-08-17 , DOI: 10.1016/j.drup.2024.101139
Ruishan Liu 1 , Yingying Chen 2 , Hao Xu 1 , Huanran Zhang 3 , Yi Liu 1 , Xiaojing Liu 4 , Haowei Ye 1 , Mantao Chen 5 , Beiwen Zheng 6
Affiliation  

Herein, we first isolated two MCR-9- and KPC-2-co-producing K. pneumoniae isolates. Notably, we observed a fusion event between the chromosome and plasmid, mediated by IS903B, in these two strains. This cointegration of chromosomes and plasmids introduces a new mode of transmission for antimicrobial resistance genes.

中文翻译:


在两个共生产 MCR-9 和 KPC-2 的肺炎克雷伯菌分离株中,由 IS903B 介导的染色体和质粒之间的融合事件



在此,我们首先分离了两种 MCR-9 和 KPC-2 共生产肺炎克雷伯菌分离株。值得注意的是,我们在这两个菌株中观察到由 IS903B 介导的染色体和质粒之间的融合事件。染色体和质粒的这种共整合引入了抗菌素耐药基因的新传播模式。
更新日期:2024-08-17
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