Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae,Drug Resistance Updates

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Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2024-08-16 , DOI: 10.1016/j.drup.2024.101138
Xueqing Wu ₁ , Babek Alibayov ₂ , Xi Xiang ₃ , Santiago M Lattar ₄ , Fuminori Sakai ₄ , Austin A Medders ₅ , Brenda S Antezana ₆ , Lance E Keller ₇ , Ana G J Vidal ₅ , Yih-Ling Tzeng ₆ , D Ashley Robinson ₇ , David S Stephens ₆ , Yunsong Yu ₁ , Jorge E Vidal ₇

Affiliation

Department of Infectious Diseases, Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, China; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou 310052, China.
Center for Immunology and Microbial Research, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China.
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, United States; Graduate Program in Microbiology and Molecular Genetics, Emory University, Atlanta, GA 30322, United States.
Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, United States; Center for Immunology and Microbial Research, University of Mississippi Medical Center, Jackson, MS 39216, United States.

To investigate the molecular events associated with acquiring macrolide resistance genes [mefE/mel (Mega) or ermB] in Streptococcus pneumoniae (Spn) during nasopharyngeal colonization.

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