Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium,Gastroenterology

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Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium
Gastroenterology ( IF 25.7 ) Pub Date : 2024-08-09 , DOI: 10.1053/j.gastro.2024.07.008
Sara Rahmani ₁ , Heather J Galipeau ₂ , Alexandra V Clarizio ₂ , Xuanyu Wang ₂ , Amber Hann ₂ , Gaston H Rueda ₂ , Utkarshini N Kirtikar ₂ , Marco Constante ₂ , Mark Wulczynski ₂ , Hsuan-Ming Su ₃ , Rebecca Burchett ₄ , Jonathan L Bramson ₄ , Maria Ines Pinto-Sanchez ₂ , Juan Pablo Stefanolo ₅ , Sonia Niveloni ₅ , Michael G Surette ₂ , Joseph A Murray ₆ , Robert P Anderson ₇ , Premysl Bercik ₂ , Alberto Caminero ₂ , Fernando G Chirdo ₈ , Tohid F Didar ₉ , Elena F Verdu ₂

Affiliation

School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada.
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
C. Bonorino Udaondo Hospital, Buenos Aires, Argentina.
Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Mackay Base Hospital, Mackay, Queensland, Australia.
Instituto de Estudios Inmunológicos y Fisiopatológicos - IIFP (UNLP-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada.

Intestinal epithelial cell (IEC) damage is a hallmark of celiac disease (CeD); however, its role in gluten-dependent T-cell activation is unknown. We investigated IEC-gluten-T-cell interactions in organoid monolayers expressing human major histocompatibility complex class II (HLA-DQ2.5), which facilitates gluten antigen recognition by CD4+ T cells in CeD.

中文翻译：

表达 MHC II 类的上皮细胞对 CD4 + T 细胞的麸质依赖性激活

肠上皮细胞（IEC）损伤是乳糜泻（CeD）的标志;然而，它在麸质依赖性 T 细胞活化中的作用尚不清楚。我们研究了表达人类主要组织相容性复合体 II 类（HLA-DQ2.5）的类器官单层中的 IEC-麸质-T 细胞相互作用，这促进了 CeD 中 CD4+ T 细胞对麸质抗原的识别。

更新日期：2024-08-09

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