Adenosine-to-Inosine (A-to-I), one of the most prevalent RNA modifications, has recently garnered significant attention. The A-to-I modification actively contributes to biological and pathological processes by affecting the structure and function of various RNA molecules, including double stranded RNA, transfer RNA, microRNA, and viral RNA. Increasing evidence suggests that A-to-I plays a crucial role in the development of human disease, particularly in cancer, and aberrant A-to-I levels are closely associated with tumorigenesis and progression through regulation of the expression of multiple oncogenes and tumor suppressor genes. Currently, the underlying molecular mechanisms of A-to-I modification in cancer are not comprehensively understood. Here, we review the latest advances regarding the A-to-I editing pathways implicated in cancer, describing their biological functions and their connections to the disease.

中文翻译：

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癌症中的腺苷-肌苷 RNA 编辑：分子机制和下游靶标。


腺苷-肌苷 （A-to-I） 是最普遍的 RNA 修饰之一，最近引起了广泛关注。A-to-I 修饰通过影响各种 RNA 分子（包括双链 RNA、转移 RNA、microRNA 和病毒 RNA）的结构和功能，积极促进生物和病理过程。越来越多的证据表明，A-to-I 在人类疾病的发展中起着至关重要的作用，尤其是在癌症中，异常的 A-to-I 水平通过调节多个癌基因和肿瘤抑制基因的表达与肿瘤发生和进展密切相关。目前，癌症中 A-to-I 修饰的潜在分子机制尚不清楚。在这里，我们回顾了与癌症相关的 A-to-I 编辑途径的最新进展，描述了它们的生物学功能及其与疾病的联系。