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Age-Related Blood Pressure Gradients Are Associated With Blood Pressure Control and Global Population Outcomes.
Hypertension ( IF 6.9 ) Pub Date : 2024-08-07 , DOI: 10.1161/hypertensionaha.124.23406
Janis M Nolde 1, 2 , Thomas Beaney 3 , Revathy Carnagarin 1 , George S Stergiou 4 , Neil R Poulter 3 , Aletta E Schutte 5, 6, 7 , Markus P Schlaich 1, 8, 9
Affiliation  

BACKGROUND The strong relationship between blood pressure (BP) and age is well known. Limited evidence suggests that a steeper age-BP slope may be associated with an increased risk of adverse outcomes. The May Measurement Month campaign enables an investigation of geographic, socioeconomic, and sex differences in age-related BP gradients and their association with public-health outcomes. METHODS Cross-sectional, annual global BP May Measurement Month screening data were analyzed. Average systolic BP and age-related BP slopes across different age groups were calculated to assess regional, socioeconomic, and sex-stratified variations. The association of BP slopes derived from adjusted linear regression models with country-level health metrics was investigated. RESULTS Age-related systolic BP gradients differed distinctly across global geographic regions, income levels, and between sexes. The steepest age gradients of BP were observed in populations from Africa and Europe. Women had lower BP levels than men at younger ages (20s and 30s) but subsequently experienced more pronounced age-related BP gradients. Geographically divergent age-related BP gradients were significantly associated with major national public health indicators. Globally, steeper age-related BP slopes were associated with poor BP control, increased disability-adjusted life years, and death rates. A steeper population age-BP slope of 1 mm Hg per 10 years was associated with a decrease in life expectancy of 3.3 years in this population (95% CI, -5.1 to -1.4; P=0.0007). CONCLUSIONS Age-related BP gradients vary considerably across global populations and are associated with variability in BP-related risks and adverse outcomes across regions. Effective public health strategies may require region-specific targeting of adverse BP gradients to improve health outcomes.

中文翻译:


与年龄相关的血压梯度与血压控制和全球人口结果相关。



背景技术众所周知,血压(BP)和年龄之间的密切关系。有限的证据表明,年龄-血压斜率较陡可能与不良后果风险增加相关。五月测量月活动能够调查与年龄相关的血压梯度的地理、社会经济和性别差异及其与公共卫生结果的关系。方法 对年度全球血压五月测量月筛查数据进行横断面分析。计算不同年龄组的平均收缩压和与年龄相关的血压斜率,以评估区域、社会经济和性别分层的变化。研究了调整后的线性回归模型得出的血压斜率与国家级健康指标的关联。结果 与年龄相关的收缩压梯度在全球地理区域、收入水平和性别之间存在明显差异。在非洲和欧洲人群中观察到 BP 的年龄梯度最陡。年轻时(20 岁和 30 岁)女性的血压水平低于男性,但随后经历了更明显的与年龄相关的血压梯度。地理上不同的年龄相关血压梯度与主要的国家公共卫生指标显着相关。在全球范围内,与年龄相关的血压斜率陡峭与血压控制不良、伤残调整生命年增加和死亡率相关。人群年龄-血压斜率每 10 年 1 毫米汞柱,与该人群预期寿命缩短 3.3 年相关(95% CI,-5.1 至 -1.4;P=0.0007)。结论 全球人群中与年龄相关的血压梯度差异很大,并且与各地区血压相关风险和不良后果的变异性相关。 有效的公共卫生策略可能需要针对特定​​区域的不良血压梯度进行针对性治疗,以改善健康结果。
更新日期:2024-08-07
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