Intrathecal morphine provides effective analgesia for a range of operations. However, widespread implementation into clinical practice is hampered by concerns for potential side-effects. We undertook a systematic review, meta-analysis, and meta-regression with the primary objective of determining whether a threshold dose for non-pulmonary complications could be defined and whether an association could be established between dose and complication rates when intrathecal morphine is administered for perioperative or obstetric analgesia.

中文翻译：

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鞘内注射吗啡的非肺部并发症： 荟萃回归的系统评价和荟萃分析


鞘内注射吗啡为一系列手术提供有效的镇痛作用。然而，由于担心潜在的副作用，阻碍了在临床实践中的广泛实施。我们进行了系统评价、meta 分析和 meta 回归分析，主要目的是确定是否可以定义非肺部并发症的阈值剂量，以及是否可以在鞘内注射吗啡进行围手术期或产科镇痛时确定剂量与并发症发生率之间的关联。