The use of 50+ year-old donors for heart transplant (HT) is rare in the United States. We assessed reasons for this-and whether it reflects concern about age itself or associated risk factors-using a survey of US HT centers. The Donor Heart Study enrolled US adult potential heart donors from 2015 to 2020. A total of 6,814 surveys across 2,197 donors cited, on average, 2.4 reasons (per donor) for offer refusal. Age was cited often (by ≥50% of centers surveyed) for 715 donors (33%). In this subgroup, accompanying donor-related reasons for refusal were infrequent, with no cardiac abnormality cited in most cases. Donor age showed associations with (1) age as a reason for refusal and (2) discard. Both abruptly increased at age 50: 55% of 50 to 51-year-old donors were refused often due to age (vs 38% of 48-49-year-olds), and 72% were discarded (vs 55% of 48-49-year-olds), despite no evidence of a threshold effect of age on outcomes.

中文翻译：

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只是一个数字？供体年龄和（缺乏）心脏报价拒绝的相关原因。


在美国，使用 50+ 岁的供体进行心脏移植 （HT） 的情况很少见。我们使用对美国 HT 中心的调查评估了造成这种情况的原因，以及它是否反映了对年龄本身或相关风险因素的担忧。供体心脏研究在 2015 年至 2020 年期间招募了美国成年潜在心脏供体。2197 名捐助者的 6814 次调查平均引用了 2.4 个拒绝录用的原因（每个捐助者）。715 名捐献者 （33%） 经常引用年龄 （≥50% 的受访中心）。在该亚组中，伴随的与供体相关的拒绝原因并不常见，大多数病例没有引用心脏异常。供体年龄与 （1） 年龄作为拒绝原因和 （2） 丢弃相关。两者在 50 岁时均突然增加：55% 的 50 至 51 岁供体经常因年龄而被拒绝（48-49 岁为 38%），72% 被丢弃（48-49 岁为 55%），尽管没有证据表明年龄对结局的阈值效应。