The recent worldwide surge of warfare and hostilities exposes increasingly large numbers of individuals to traumatic events, placing them at risk of developing posttraumatic stress disorder (PTSD) and challenging both clinicians and service delivery systems. This overview summarizes and updates the core knowledge of the genetic, molecular, and neural circuit features of the neurobiology of PTSD and advances in evidence-based psychotherapy, pharmacotherapy, neuromodulation, and digital treatments. While the complexity of the neurobiology and the biological and clinical heterogeneity of PTSD have challenged clinicians and researchers, there is an emerging consensus concerning the underlying mechanisms and approaches to diagnosis, treatment, and prevention of PTSD. This update addresses PTSD diagnosis, prevalence, course, risk factors, neurobiological mechanisms, current standard of care, and innovations in next-generation treatment and prevention strategies. It provides a comprehensive summary and concludes with areas of research for integrating advances in the neurobiology of the disorder with novel treatment and prevention targets.

中文翻译：

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神经生物学和创伤后应激障碍的治疗。


最近全球范围内战争和敌对行动的激增使越来越多的人遭受创伤事件，使他们面临患上创伤后应激障碍 (PTSD) 的风险，并对临床医生和服务提供系统提出挑战。本概述总结并更新了 PTSD 神经生物学的遗传、分子和神经回路特征的核心知识，以及循证心理治疗、药物治疗、神经调节和数字治疗的进展。虽然神经生物学的复杂性以及 PTSD 的生物学和临床异质性给临床医生和研究人员带来了挑战，但关于 PTSD 的潜在机制和诊断、治疗和预防方法正在形成共识。本次更新涉及 PTSD 的诊断、患病率、病程、危险因素、神经生物学机制、当前护理标准以及下一代治疗和预防策略的创新。它提供了全面的总结，并总结了将该疾病的神经生物学进展与新的治疗和预防目标相结合的研究领域。