Temperature-dependent alternative splicing (AS) is a crucial mechanism for organisms to adapt to varying environmental temperatures. In mammals, even slight fluctuations in body temperature are sufficient to drive significant AS changes in a concerted manner. This dynamic regulation allows organisms to finely tune gene expression and protein isoform diversity in response to temperature cues, ensuring proper cellular function and physiological adaptation. Understanding the molecular mechanisms underlying temperature-dependent AS thus provides valuable insights into the intricate interplay between environmental stimuli and gene expression regulation. In this review, we provide an overview of recent advances in understanding temperature-regulated AS across various biological processes and systems. We will discuss the machinery sensing and translating temperature cues into changed AS patterns, the adaptation of the splicing regulatory machinery to extreme temperatures, the role of temperature-dependent AS in shaping the transcriptome, functional implications and the development of potential therapeutics targeting temperature-sensitive AS pathways.

中文翻译：

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温度调节转录组学：温度依赖性选择性剪接的分子基础和生物学意义。


温度依赖性选择性剪接（AS）是生物体适应不同环境温度的重要机制。在哺乳动物中，即使体温的轻微波动也足以以协调的方式驱动显着的 AS 变化。这种动态调节使生物体能够根据温度线索微调基因表达和蛋白质亚型多样性，确保适当的细胞功能和生理适应。因此，了解温度依赖性 AS 的分子机制为了解环境刺激和基因表达调控之间复杂的相互作用提供了宝贵的见解。在这篇综述中，我们概述了了解各种生物过程和系统中温度调节 AS 的最新进展。我们将讨论机械感测并将温度线索转化为改变的 AS 模式、剪接调节机制对极端温度的适应、温度依赖性 AS 在转录组塑造中的作用、功能意义以及针对温度敏感的潜在疗法的开发AS途径。