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Neutralizing Antibodies Targeting BK Polyomavirus: Clinical Importance and Therapeutic Potential for Kidney Transplant Recipients
Journal of the American Society of Nephrology ( IF 10.3 ) Pub Date : 2024-07-09 , DOI: 10.1681/asn.0000000000000457 Francois Helle 1 , Aurélien Aubry 1, 2 , Virginie Morel 1, 2 , Véronique Descamps 1, 2 , Baptiste Demey 1, 2 , Etienne Brochot 1, 2
Journal of the American Society of Nephrology ( IF 10.3 ) Pub Date : 2024-07-09 , DOI: 10.1681/asn.0000000000000457 Francois Helle 1 , Aurélien Aubry 1, 2 , Virginie Morel 1, 2 , Véronique Descamps 1, 2 , Baptiste Demey 1, 2 , Etienne Brochot 1, 2
Affiliation
a functional cellular response is impaired by immunosuppression, neutralizing antibodies may play a major role because they can directly prevent infection of target cells, independently of cell-mediated immunity, by binding to the viral particles. Studying the contribution of anti-BK virus neutralizing antibodies in viral control has long been hampered by the lack of convenient in vitro models, but major progress has been made in the past decade. The four BK virus genotypes have been demonstrated to behave as distinct serotypes. A low recipient neutralizing antibody titer against the donor's serotype before kidney transplant has been significantly associated with BK virus replication after transplant. Different mechanisms exploited by the BK virus to evade neutralizing antibodies have been described. Recent studies also support the potential benefit of administering intravenous Igs or monoclonal neutralizing antibodies as a therapeutic strategy, and more interestingly, this could also be used as preventive or preemptive therapy before advanced kidney damage has occurred. Besides, neutralizing antibodies could be induced by vaccination. In this review, we summarize accumulated knowledge on anti-BK virus neutralizing antibodies as well as their clinical importance and therapeutic potential for kidney transplant recipients....
中文翻译:
针对 BK 多瘤病毒的中和抗体:对肾移植受者的临床重要性和治疗潜力
功能性细胞反应因免疫抑制而受损,中和抗体可能发挥重要作用,因为它们可以通过与病毒颗粒结合,独立于细胞介导的免疫而直接防止靶细胞的感染。长期以来,由于缺乏方便的体外模型,研究抗 BK 病毒中和抗体在病毒控制中的贡献一直受到阻碍,但在过去十年中已经取得了重大进展。四种 BK 病毒基因型已被证明具有不同的血清型。肾移植前针对供体血清型的受者中和抗体滴度较低与移植后 BK 病毒复制显着相关。已经描述了 BK 病毒利用不同的机制来逃避中和抗体。最近的研究还支持静脉注射 Igs 或单克隆中和抗体作为治疗策略的潜在益处,更有趣的是,这也可以用作晚期肾损伤发生之前的预防性或先发性治疗。此外,疫苗接种可以诱导中和抗体。在这篇综述中,我们总结了抗 BK 病毒中和抗体的积累知识及其临床重要性和对肾移植受者的治疗潜力......
更新日期:2024-07-09
中文翻译:
针对 BK 多瘤病毒的中和抗体:对肾移植受者的临床重要性和治疗潜力
功能性细胞反应因免疫抑制而受损,中和抗体可能发挥重要作用,因为它们可以通过与病毒颗粒结合,独立于细胞介导的免疫而直接防止靶细胞的感染。长期以来,由于缺乏方便的体外模型,研究抗 BK 病毒中和抗体在病毒控制中的贡献一直受到阻碍,但在过去十年中已经取得了重大进展。四种 BK 病毒基因型已被证明具有不同的血清型。肾移植前针对供体血清型的受者中和抗体滴度较低与移植后 BK 病毒复制显着相关。已经描述了 BK 病毒利用不同的机制来逃避中和抗体。最近的研究还支持静脉注射 Igs 或单克隆中和抗体作为治疗策略的潜在益处,更有趣的是,这也可以用作晚期肾损伤发生之前的预防性或先发性治疗。此外,疫苗接种可以诱导中和抗体。在这篇综述中,我们总结了抗 BK 病毒中和抗体的积累知识及其临床重要性和对肾移植受者的治疗潜力......