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Prenatal cell-free DNA screening for chromosomal aneuploidies after euploid embryo transfer shows high concordance with preimplantation genetic testing for aneuploidy results and low positive predictive values
Fertility and Sterility ( IF 6.6 ) Pub Date : 2024-07-27 , DOI: 10.1016/j.fertnstert.2024.07.029
Mitko Madjunkov 1 , Prati Sharma 1 , Ari Baratz 1 , Karen Glass 1 , Rina Abramov 2 , Nicole Logan 2 , Svetlana Madjunkova 3 , Clifford Librach 4
Affiliation  

To evaluate the positive predictive value (PPV) of prenatal cell-free DNA (cfDNA) screening for chromosomal aneuploidies in pregnancies achieved either after single euploid transfer in in vitro fertilization or Preimplantation Genetic Testing for Aneuploidy (PGT-A) cycles or transfer of single untested embryo, and to assess the concordance of prenatal-cfDNA-screening and PGT-A results.

中文翻译:


整倍体胚胎移植后染色体非整倍体的产前游离 DNA 筛查显示与植入前非整倍体结果的基因检测高度一致,阳性预测值低



评估体外受精中单个整倍体移植 或植入前非整倍体基因检测 (PGT-A) 周期或单个未经测试的胚胎移植后实现的产前游离 DNA (cfDNA) 筛查对妊娠染色体非整倍体的阳性预测值 (PPV),并评估产前 cfDNA 筛查和 PGT-A 结果的一致性。
更新日期:2024-07-27
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