Elevated airborne PCB levels in older schools are concerning due to their health impacts, including cancer, metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular issues, neurodevelopmental diseases, and diabetes. During a four-week inhalation exposure to PCB52, an air pollutant commonly found in school environments, adolescent rats exhibited notable presence of PCB52 and its hydroxylated forms in their livers, alongside changes in gene expression. Female rats exhibited more pronounced changes in gene expression compared to males, particularly in fatty acid synthesis genes regulated by the transcription factor SREBP1. studies with human liver cells showed that the hydroxylated metabolite of PCB52, 4-OH-PCB52, but not the parent compound, upregulated genes involved in fatty acid biosynthesis similar to exposure. These findings highlight the sex-specific effects of PCB52 exposure on livers, particularly in females, suggesting a potential pathway for increased MASLD susceptibility.

中文翻译：

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吸入暴露于 PCB52（2,2′，5,5′-四氯联苯）引起的青春期雌性大鼠肝脏脂肪酸合成基因的上调


由于对健康的影响，包括癌症、代谢功能障碍相关的脂肪性肝病 （MASLD）、心血管问题、神经发育疾病和糖尿病，较老学校空气中的 PCB 水平升高令人担忧。在吸入 PCB52（学校环境中常见的一种空气污染物）为期 4 周期间，青春期大鼠在肝脏中表现出 PCB52 及其羟基化形式的显着存在，以及基因表达的变化。与雄性大鼠相比，雌性大鼠的基因表达变化更明显，尤其是在转录因子 SREBP1 调控的脂肪酸合成基因中。对人肝细胞的研究表明，PCB52 的羟基化代谢物 4-OH-PCB52，而不是母体化合物，上调参与脂肪酸生物合成的基因，类似于暴露。这些发现强调了 PCB52 暴露对肝脏的性别特异性影响，尤其是在女性中，这表明 MASLD 易感性增加的潜在途径。