Life expectancy has increased worldwide alongside a rise in disability prevalence during old age. The impact and interrelationship among the precursors of disability in midlife remain to be better understood. Furthermore, investigating whether lifestyle factors may potentially influence health outcomes and the prognosis of vascular disease could be especially relevant among the middle-aged population, which is a priority subpopulation when prevention is the goal. This is an observational, cross-sectional and population-based study. Participants, between 50 and 55 years old, are randomly selected from the municipality of Toledo (Spain). There are six non-consecutive days for the assessments, providing enough rest between evaluations. Participants perform the interview of the Toledo Study for Healthy Aging. Blood pressure monitoring and a resting electrocardiogram are also recorded. Then, resting peripheral and cerebral vascular measurements along with muscle size and architecture are assessed. Blood and urine samples, and body composition data are collected after an overnight fasting. On a different visit, physical performance and muscle function tests are performed. Additionally, brain magnetic resonance imaging is conducted. And finally, an accelerometer is given to the participants for a week. Frailty is evaluated by Frailty Trait Scale and Fried Frailty Phenotype. This project will shed light on the associations between frailty, early cognitive impairment, and vascular aging during midlife, and on the role that lifestyles play in their development. Lastly, this project will provide meaningful implications for public health strategies aimed at promoting healthy aging in later life.

中文翻译：

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中年成年人衰弱、早期血管衰退和亚临床认知障碍的影响：托莱多中年健康老龄化研究的研究方案。


随着老年残疾发生率的上升，全世界的预期寿命都在增加。中年残疾先兆之间的影响和相互关系仍有待更好地理解。此外，调查生活方式因素是否可能影响健康结果和血管疾病的预后对于中年人群尤其重要，当以预防为目标时，中年人群是优先考虑的亚人群。这是一项基于人群的观察性、横断面研究。参与者年龄在 50 至 55 岁之间，是从托莱多市（西班牙）随机选出的。评估有六天不连续的时间，在评估之间提供足够的休息时间。参与者接受托莱多健康老龄化研究的采访。还记录血压监测和静息心电图。然后，评估静息外周血管和脑血管测量以及肌肉大小和结构。禁食过夜后收集血液和尿液样本以及身体成分数据。在另一次访问中，进行身体表现和肌肉功能测试。此外，还进行脑磁共振成像。最后，为参与者提供为期一周的加速度计。衰弱通过衰弱特质量表和Fried衰弱表型进行评估。该项目将揭示中年虚弱、早期认知障碍和血管老化之间的关联，以及生活方式在其发展中所起的作用。最后，该项目将为旨在促进晚年健康老龄化的公共卫生战略提供有意义的影响。