INTRODUCTION The risk of small bowel cancer (SBC) in inflammatory bowel disease (IBD) is unclear. We compared the recent trends of SBC in patients with IBD and stratified them based on disease type. METHODS We used TriNetX database to access the electronic health records for patients with IBD, ulcerative colitis (UC) and Crohn's disease (CD) from 2005-2024. We used propensity score matching to compare the rate of SBC in patients with IBD, UC, and CD compared to the general population. We adjusted for all known confounders. RESULTS From 2010-2024, there was an increasing trend of diagnosed SBC in patients with IBD, with an Average Annual Percentage Change (AAPC) of 3.2% (P<0.001). Patients with CD (aHR = 4.83; 95% CI: 3.58 - 6.53; P < .0001) had an increased risk of SBC compared to the general population without IBD, as well as patients with UC (aHR = 2.28; 95% CI: 1.65 - 3.14; P < .0001). The ileum was the most common location across all subgroups. CONCLUSION Both patients with CD and, interestingly, UC had an elevated risk for developing SBC compared to the general population.

中文翻译：

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炎症性肠病中小肠癌的风险：来自美国大型多中心数据库的倾向匹配研究。


简介 炎症性肠病 (IBD) 中小肠癌 (SBC) 的风险尚不清楚。我们比较了 IBD 患者 SBC 的最新趋势，并根据疾病类型对它们进行了分层。方法 我们使用 TriNetX 数据库访问 2005 年至 2024 年 IBD、溃疡性结肠炎 (UC) 和克罗恩病 (CD) 患者的电子健康记录。我们使用倾向评分匹配来比较 IBD、UC 和 CD 患者与一般人群的 SBC 发生率。我们对所有已知的混杂因素进行了调整。结果 2010-2024年，IBD患者诊断为SBC呈增加趋势，年均百分比变化（AAPC）为3.2%（P<0.001）。与没有 IBD 的一般人群以及 UC 患者（aHR = 2.28；95% CI： 1.65 - 3.14；P < .0001)。回肠是所有亚组中最常见的位置。结论 与一般人群相比，患有 CD 和 UC 的患者发生 SBC 的风险较高。