Chronic Fatigue Syndrome (CFS) is a complex and perplexing medical disorder primarily characterized by persistent and debilitating fatigue, often accompanied by a constellation of symptoms, including weakness, dyspnea, arthromyalgia, sore throat, and disrupted sleep patterns. CFS is defined by its persistent or recurrent manifestation for a minimum duration of six months, marked by an enduring and unrelenting fatigue that remains refractory to rest. In recent decades, this condition has garnered significant attention within the medical community. While the precise etiology of CFS remains elusive, it is postulated to be multifactorial. CFS is potentially associated with various contributory factors such as infections, chronic stress, genetic predisposition, immune dysregulation, and psychosocial influences. The pathophysiological underpinnings of CFS encompass viral infections, immune system dysregulation, neuroendocrine aberrations, heightened oxidative stress, and perturbations in gut microbiota. Presently, clinical management predominantly relies on pharmaceutical interventions or singular therapeutic modalities, offering alleviation of specific symptoms but exhibiting inherent limitations. Traditional Chinese Medicine (TCM) interventions have emerged as a promising paradigm, demonstrating notable efficacy through their multimodal, multi-target, multi-pathway approach, and holistic regulatory mechanisms. These interventions effectively address the lacunae in contemporary medical interventions. This comprehensive review synthesizes recent advancements in the understanding of the etiological factors, pathophysiological mechanisms, and interventional strategies for CFS, drawing from a corpus of domestic and international literature. Its aim is to furnish valuable insights for clinicians actively involved in diagnosing and treating CFS, as well as for pharmaceutical researchers delving into innovative drug development pathways. Moreover, it seeks to address the intricate challenges confronted by clinical practitioners in managing this incapacitating condition.

中文翻译：

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慢性疲劳综合征发病机制及中西医治疗研究进展


慢性疲劳综合症 (CFS) 是一种复杂而令人费解的疾病，主要特征是持续的、令人衰弱的疲劳，通常伴有一系列症状，包括虚弱、呼吸困难、关节肌痛、喉咙痛和睡眠模式紊乱。 CFS 的定义是其持续或反复出现的症状至少持续六个月，其特点是持续且难以休息的疲劳。近几十年来，这种情况引起了医学界的高度关注。虽然 CFS 的确切病因仍然难以捉摸，但据推测它是多因素造成的。 CFS 可能与各种促成因素有关，例如感染、慢性压力、遗传倾向、免疫失调和社会心理影响。 CFS 的病理生理学基础包括病毒感染、免疫系统失调、神经内分泌异常、氧化应激加剧和肠道微生物群扰动。目前，临床管理主要依赖于药物干预或单一治疗方式，可以缓解特定症状，但表现出固有的局限性。中医干预已成为一种有前途的范例，通过其多模式、多目标、多途径方法和整体调节机制显示出显着的疗效。这些干预措施有效地解决了当代医疗干预措施的缺陷。这篇综合综述借鉴了国内外文献，综合了对 CFS 病因、病理生理机制和干预策略的理解的最新进展。 其目的是为积极参与诊断和治疗 CFS 的临床医生以及深入研究创新药物开发途径的药物研究人员提供宝贵的见解。此外，它还试图解决临床医生在管理这种失能疾病时所面临的复杂挑战。