Aging is associated with chronic oxidative stress, which contributes to the deterioration of the immune system, increasing morbidity and mortality. A positive social environment permits health maintenance and a slower rate of aging. Improvements in immune function and oxidative stress were shown in peritoneal leukocytes and organs of old mice and adult prematurely aging mice (PAM) after cohabitation with adults or exceptional non-prematurely aging mice (ENPAM), respectively, for 2 months, but adults and ENPAM experienced deterioration. This was solved by shortening the cohabitation time to 15 minutes per day for 2 months, where old mice and PAM maintained immune and redox state improvements in their peritoneal leukocytes, as well as a greater longevity, and adults and ENPAM did not show deterioration. However, it is unknown whether the positive effects of this short cohabitation are reflected in the immunity and redox state of the organs. The aim of the present study was to test whether a cohabitation of 15 minutes per day for 2 months maintains these positive effects in the organs of retired breeder female old mice and PAM and avoids the negative ones in adults and ENPAM. After cohabitation the animals were sacrificed, and the thymus and spleen were extracted to evaluate the immune function. The oxidative state was also analyzed in the spleen, liver, heart, lung, and kidney. The results show that after cohabitation, old mice and PAM improved their immunity and redox state, and adults and ENPAM showed no deterioration. This cohabitation can be suggested to improve health and slow down aging.

中文翻译：

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与成年小鼠进行短暂的社交互动后，老年和过早衰老的雌性小鼠几个器官免疫功能和氧化还原状态的改善


衰老与慢性氧化应激有关，这会导致免疫系统恶化，增加发病率和死亡率。积极的社会环境可以保持健康并减缓衰老速度。与成年小鼠或特殊非过早衰老小鼠 （ENPAM） 同居 2 个月后，老年小鼠和成年过早衰老小鼠 （PAM） 的腹膜白细胞和器官免疫功能和氧化应激有所改善，但成人和 ENPAM 经历了恶化。通过将同居时间缩短到每天 15 分钟，持续 2 个月解决了这个问题，其中老年小鼠和 PAM 保持了腹膜白细胞的免疫和氧化还原状态改善，以及更长的寿命，而成年和 ENPAM 没有表现出恶化。然而，目前尚不清楚这种短暂同居的积极影响是否反映在器官的免疫力和氧化还原状态上。本研究的目的是测试每天 15 分钟的同居，持续 2 个月是否能在退休饲养员雌性老鼠和 PAM 的器官中保持这些积极影响，并避免在成年小鼠和 ENPAM 的器官中保持这些积极影响。同居后，处死动物，提取胸腺和脾脏，评价免疫功能。还分析了脾脏、肝脏、心脏、肺和肾脏的氧化状态。结果表明，同居后，老年小鼠和 PAM 的免疫力和氧化还原状态有所提高，而成小鼠和 ENPAM 没有表现出恶化。这种同居可以被认为可以改善健康和延缓衰老。