Failure in cancer treatment often stems from drug resistance, which can manifest as either intrinsic (pre-existing) or acquired (induced by drugs). Despite extensive efforts, overcoming this resistance remains a challenging task due to the intricate and highly individualized biological mechanisms involved. This paper introduces an innovative extension of an already well-established mathematical model to account for tumour resistance development against chemotherapy.

中文翻译：

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肿瘤化疗耐药模型的渐近动力学和最佳治疗


癌症治疗的失败通常源于耐药性，耐药性可以表现为内在的（预先存在的）或获得性的（由药物引起的）。尽管付出了巨大的努力，克服这种耐药性仍然是一项具有挑战性的任务，因为其中涉及复杂且高度个性化的生物机制。本文介绍了对已经完善的数学模型的创新扩展，以解释肿瘤对化疗的耐药性的发展。