Development and Validation of a Noninvasive Model for the Detection of High-Risk Varices in Patients With Unresectable Hepatocellular Carcinoma,Clinical Gastroenterology and Hepatology

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Development and Validation of a Noninvasive Model for the Detection of High-Risk Varices in Patients With Unresectable Hepatocellular Carcinoma
Clinical Gastroenterology and Hepatology ( IF 11.6 ) Pub Date : 2024-07-30 , DOI: 10.1016/j.cgh.2024.07.008
Neehar D Parikh ₁ , Patricia Jones ₂ , Reena Salgia ₃ , Irun Bhan ₄ , Lauren T Grinspan ₅ , Janice H Jou ₆ , Kali Zhou ₇ , Prasun Jalal ₈ , Giorgio Roccaro ₉ , Amol S Rangnekar ₁₀ , Jihane N Benhammou ₁₁ , Anjana Pillai ₁₂ , Neil Mehta ₁₃ , Joel Wedd ₁₄ , Ju Dong Yang ₁₅ , Amy K Kim ₁₆ , Andres Duarte-Rojo ₁₇ , Omobonike O Oloruntoba ₁₈ , Amit Tevar ₁₉ , Jennifer S Au ₂₀ , Yamile Blain ₂ , Sanjana Rao ₂ , Onofrio A Catalano ₄ , Sara Lewis ₅ , Mishal Mendiratta-Lala ₁ , Kevin King ₇ , Lekha Sachdev ₁₀ , Edward W Lee ₁₁ , Jill Bruno ₁₄ , Ihab Kamel ₁₆ , Celestina Tolosa ₁₆ , Karissa Kao ₁ , Tarek Badawi ₃ , Eric M Przybyszewski ₄ , Lisa Quirk ₂₁ , Piyush Nathani ₂₁ , Brandy Haydel ₅ , Emily Leven ₅ , Nicole Wong ₆ , Robert Albertian ₇ , Ariana Chen ₇ , Fuad Z Aloor ₈ , Islam B Mohamed ₈ , Ahmed Elkheshen ₈ , Charles Marvil ₉ , Gerard Issac ₉ , Joseph W Clinton ₁₀ , Stephanie M Woo ₁₀ , Jung Yum ₁₁ , Erin Rieger ₁₂ , Alan L Hutchison ₁₂ , Don A Turner ₁₄ , Manaf Alsudaney ₁₅ , Perla Hernandez ₁₅ , Ziyi Xu ₁₆ , Abdullah Khalid ₂₀ , Bethany Barrick ₂₀ , Bo Wang ₁ , Elliot B Tapper ₁ , Wei Hao ₁ , Amit G Singal ₂₁

Affiliation

University of Michigan, Ann Arbor, Michigan.
University of Miami, Miami, Florida.
Henry Ford Health, Detroit, Michigan.
Massachusetts General Hospital, Boston, Massachusetts.
The Mount Sinai Hospital, New York, New York.
Oregon Health Science University, Portland, Oregon.
University of Southern California, Los Angeles, California.
Baylor College of Medicine, Houston, Texas.
Emory University, Atlanta, Georgia.
Georgetown University, Washington, District of Columbia.
University of California Los Angeles, Los Angeles, California.
University of Chicago, Chicago, Illinois.
University of San Francisco, San Francisco, California.
Virginia Commonwealth University, Richmond, Virginia.
Cedars-Sinai Medical Center, Los Angeles, California.
Johns Hopkins University, Baltimore, Maryland.
Northwestern University, Chicago, Illinois.
Duke University, Durham, North Carolina.
University of Pittsburgh, Pittsburgh, Pennsylvania.
Scripps Health, San Diego, California.
University of Texas Southwestern, Dallas, Texas.

Noninvasive variceal risk stratification systems have not been validated in patients with hepatocellular carcinoma (HCC), which presents logistical barriers for patients in the setting of systemic HCC therapy. We aimed to develop and validate a noninvasive algorithm for the prediction of varices in patients with unresectable HCC.

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