Organochlorine pesticides (OCPs) show differences in their chemical structure, mechanism of toxicity, and target organisms. However, OCPs also have some common characteristics such as high persistence in the environment, bioaccumulation, and toxicity which lead to health issues. Nowadays, the toxicity of OCPs is well known, but we still do not know all the specific molecular mechanisms leading to their toxicity in mammalians. Therefore, this review aims to collect data about the mode of action of various classes of OCPs, highlighting their differences and common behavioural reactions in the human and animal body. To discuss the OCPs molecular pathways and fate in different systems of the body, three organochlorine insecticides were selected (Dichlorodiphenyltrichloroethane, Hexachlorocyclohexane and Chlordecone), regarding to their widespread use, with consequent effects on the ecosystem and human health. Their common biological responses at the molecular scale and their different interactions in human and animal bodies were highlighted and presented.

中文翻译：

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不同有机氯农药家族对哺乳动物的作用方式


有机氯农药（OCP）在化学结构、毒性机制和目标生物方面表现出差异。然而，OCP 也有一些共同特征，例如在环境中的高持久性、生物蓄积性和导致健康问题的毒性。如今，OCP的毒性已众所周知，但我们仍然不知道导致其对哺乳动物产生毒性的所有具体分子机制。因此，本综述旨在收集有关各类 OCP 作用模式的数据，突出它们在人体和动物体内的差异和常见行为反应。为了讨论 OCPs 在人体不同系统中的分子途径和归宿，选择了三种有机氯杀虫剂（二氯二苯基三氯乙烷、六氯环己烷和十氯酮），因为它们的广泛使用对生态系统和人类健康产生了影响。强调并介绍了它们在分子尺度上的共同生物反应以及它们在人体和动物体内的不同相互作用。